Title : Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation.

Pub. Date : 2020 Nov 23

PMID : 33238540






1 Functional Relationships(s)
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1 We showed that EGCG elicits phosphorylation of Src at Tyr 416, a crucial phosphorylation site for its activity, and that the pharmacological inhibition of Src impedes the upstream events in EGCG-induced cell death signaling including upregulation of Akt activity, increase in cGMP levels, and activation of ASM. Tyrosine AKT serine/threonine kinase 1 Homo sapiens