Title : Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain.

Pub. Date : 2020 Dec 16

PMID : 33236886






1 Functional Relationships(s)
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1 Bispecific antibody ligands RmAb158-scFv8D3 and Tribody A2, both targeting Abeta and TfR, were functionalized with trans-cyclooctene (TCO) groups and conjugated with 18F-labeled tetrazines through an inverse electron demand Diels-Alder reaction performed at ambient temperature. Cyclooctanes transferrin receptor Mus musculus