Title : Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models.

Pub. Date : 2020 Nov

PMID : 33208364






3 Functional Relationships(s)
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1 Engineered mutant alpha-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus
2 Airway dehydration and impaired mucociliary clearance in CF is proposed to result in tonic epithelial sodium channel (ENaC) activity, which drives amiloride-sensitive electrogenic sodium absorption. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus
3 We observed a significant decrease in macroscopic as well as amiloride-sensitive ENaC currents and an increase in airway surface liquid height in CF airway cells. Amiloride sodium channel, nonvoltage-gated 1 alpha Mus musculus