Title : Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer.

Pub. Date : 2021 Jan

PMID : 33177154






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 This study highlights TTC-352"s benzothiophene scaffold that yields an H-bond with Glu353, which allows Asp351-to-helix 12 (H12) interaction; sealing ERalpha"s ligand binding domain, recruiting E2-enriched coactivators, and triggering rapid ERalpha-induced unfolded protein response (UPR) and apoptosis, as the basis of its anti-cancer properties. Estradiol estrogen receptor 1 Homo sapiens