Pub. Date : 2021 Feb
PMID : 33176060
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Skeletal muscle myosin and cardiac myosin attenuate heparin"s antithrombin-dependent anticoagulant activity. | Heparin | serpin family C member 1 | Homo sapiens |
| 2 | BACKGROUND: Heparin enhances the ability of the plasma protease inhibitor, antithrombin, to neutralize coagulation factor Xa and thrombin. | Heparin | serpin family C member 1 | Homo sapiens |
| 3 | OBJECTIVES: The aim of this study was to investigate the influence of myosin binding to heparin on antithrombin"s anticoagulant activity. | Heparin | serpin family C member 1 | Homo sapiens |
| 4 | METHODS: Inhibition of factor Xa and thrombin by antithrombin in the presence of different heparins and skeletal muscle myosin or cardiac myosin was studied by measuring inhibition of each enzyme"s chromogenic substrate hydrolysis. | Heparin | serpin family C member 1 | Homo sapiens |
| 5 | RESULTS AND CONCLUSIONS: Skeletal muscle myosin and cardiac myosin neutralized unfractionated heparin"s enhancement of antithrombin"s inhibition of purified factor Xa and thrombin. | Heparin | serpin family C member 1 | Homo sapiens |