Title : Anti‑inflammatory effects of leaf and branch extracts of honeyberry (Lonicera caerulea) on lipopolysaccharide‑stimulated RAW264.7 cells through ATF3 and Nrf2/HO‑1 activation.

Pub. Date : 2020 Dec

PMID : 33174016






2 Functional Relationships(s)
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1 HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown. Reactive Oxygen Species interleukin 1 beta Mus musculus
2 HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown. Reactive Oxygen Species interleukin 1 beta Mus musculus