Title : Enterobactin induces the chemokine, interleukin-8, from intestinal epithelia by chelating intracellular iron.

Pub. Date : 2020 Nov 9

PMID : 33171063






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Bacteria synthesize siderophores to sequester host iron, whereas lipocalin 2 (Lcn2) is the host defense protein that prevent this iron thievery. Iron lipocalin 2 Homo sapiens
2 Bacteria synthesize siderophores to sequester host iron, whereas lipocalin 2 (Lcn2) is the host defense protein that prevent this iron thievery. Iron lipocalin 2 Homo sapiens
3 Using three human IEC cell-lines with differential basal levels of Lcn2 (i.e. HT29 < DLD-1 < Caco-2/BBe), we demonstrated that iron-free Ent could induce a dose-dependent secretion of the pro-inflammatory chemokine, interleukin 8 (IL-8), in HT29 and DLD-1 IECs, but not in Caco-2/BBe. Iron lipocalin 2 Homo sapiens