Pub. Date : 2018 Jul 30
PMID : 33168516
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Compared with the rats in the control group, the rats in the model group and Dex+atipamezole group showed significantly decreased PWT and TWL (cold) and increased expression of p-STAT3 in the spinal cord (P < 0.05). | Dexmedetomidine | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 2 | In Dex group, PWT and TWL (cold) were significantly increased (P < 0.05) and p-STAT3 expression in the spinal cord was significantly decreased (P < 0.01) 60 to 120 after Dex treatment as compared with those in the model group, and these effects of Dex were significantly attenuated by the administration of atipamezole (P < 0.05). | Dexmedetomidine | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 3 | In Dex group, PWT and TWL (cold) were significantly increased (P < 0.05) and p-STAT3 expression in the spinal cord was significantly decreased (P < 0.01) 60 to 120 after Dex treatment as compared with those in the model group, and these effects of Dex were significantly attenuated by the administration of atipamezole (P < 0.05). | Dexmedetomidine | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 4 | In Dex group, PWT and TWL (cold) were significantly increased (P < 0.05) and p-STAT3 expression in the spinal cord was significantly decreased (P < 0.01) 60 to 120 after Dex treatment as compared with those in the model group, and these effects of Dex were significantly attenuated by the administration of atipamezole (P < 0.05). | Dexmedetomidine | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 5 | CONCLUSIONS: Dex can alleviate oxaliplatin-induced neuropathic pain in rats by inhibiting the phosphorylation of STAT3 in the spinal cord. | Dexmedetomidine | signal transducer and activator of transcription 3 | Rattus norvegicus |