Title : Synthetic Lethal Drug Combinations Targeting Proteasome and Histone Deacetylase Inhibitors in TP53-Mutated Cancers.

Pub. Date : 2020

PMID : 33163985






1 Functional Relationships(s)
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1 Methods: From our predictive synthetic lethality model used in SL-BioDP, we inferred TP53 mutation lead to potential synergistic drug combination of Bortezomib and Vorinostat. Bortezomib tumor protein p53 Homo sapiens