Title : Mono-dispersed nano-hydroxyapatite based MRI probe with tetrahedral DNA nanostructures modification for in vitro tumor cell imaging.

Pub. Date : 2020 Nov 22

PMID : 33161975






1 Functional Relationships(s)
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1 Taking advantage of the superior biocompatibility, good stability in a wide pH and temperature range, as well as its strong affinity with DNA of hydroxyapatite (HAp), tetrahedral DNA nanostructures (TDNs) conjugated with AS1411 aptamer (anti-nucleolin overexpressed on tumor cell membranes) were employed as affinity ligands to construct a novel mono-dispersed HAp based probe with Gd3+ doping (Apt-TDNs-GdHAp) for MR imaging. AGRO 100 nucleolin Homo sapiens