Title : Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation.

Pub. Date : 2021 Jan

PMID : 33154041






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Thus, new findings link an important role for CAR in intestinal UGT1A1 induction and its role in the intestinal maturation pathway Significance Statement Obeticholic acid (OCA) activates FXR target genes in both liver and intestinal tissues while inducing intestinal UGT1A1 which leads to the elimination of serum bilirubin in hUGT1 mice. Bilirubin nuclear receptor subfamily 1, group H, member 4 Mus musculus