Title : Functional evidence for biased inhibition of G protein signaling by YM-254890 in human coronary artery endothelial cells.

Pub. Date : 2021 Jan 15

PMID : 33152337






1 Functional Relationships(s)
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1 We conclude that YM-254890 is not a selective inhibitor for Gq protein; instead, it acts as a broad-spectrum inhibitor for Gq and Gs proteins and exhibits a biased inhibition on Gi/o signaling, without affecting non-GPCR-mediated cellular signaling. YM-254890 G protein subunit alpha i1 Homo sapiens