Pub. Date : 2021 Mar 1
PMID : 33148870
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells. | Sitagliptin Phosphate | dipeptidylpeptidase 4 | Mus musculus |
| 2 | This study aimed to investigate whether the antidiabetic drugs dipeptidyl peptidase 4 (DPP4) inhibitors such as evogliptin and sitagliptin affect the membrane DPP4 (mDPP4) enzymatic activity and immune function of T helper1 (Th1) cells in terms of cytokine expression and cell profiles. | Sitagliptin Phosphate | dipeptidylpeptidase 4 | Mus musculus |
| 3 | This study aimed to investigate whether the antidiabetic drugs dipeptidyl peptidase 4 (DPP4) inhibitors such as evogliptin and sitagliptin affect the membrane DPP4 (mDPP4) enzymatic activity and immune function of T helper1 (Th1) cells in terms of cytokine expression and cell profiles. | Sitagliptin Phosphate | dipeptidylpeptidase 4 | Mus musculus |
| 4 | This study aimed to investigate whether the antidiabetic drugs dipeptidyl peptidase 4 (DPP4) inhibitors such as evogliptin and sitagliptin affect the membrane DPP4 (mDPP4) enzymatic activity and immune function of T helper1 (Th1) cells in terms of cytokine expression and cell profiles. | Sitagliptin Phosphate | dipeptidylpeptidase 4 | Mus musculus |
| 5 | Evogliptin or sitagliptin treatment potently inhibited mDPP4 activity in a dose-dependent manner but did not affect either the cytokine profile or cell viability in PWM-activated CD4+CD26+ H9 Th1 cells. | Sitagliptin Phosphate | dipeptidylpeptidase 4 | Mus musculus |
| 6 | These results suggest that, following immune stimulation, Th1 cell signaling pathways for cytokine expression function normally after treatment with evogliptin or sitagliptin, which efficiently inhibit mDPP4 enzymatic activity in Th1 cells. | Sitagliptin Phosphate | dipeptidylpeptidase 4 | Mus musculus |