Title : Mitochondrial α7 nicotinic acetylcholine receptors are displaced from complexes with VDAC1 to form complexes with Bax upon apoptosis induction.

Pub. Date : 2020 Dec

PMID : 33147521






1 Functional Relationships(s)
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1 alpha7-selective agonist PNU282987 or type 2 positive allosteric modulator PNU120596 disrupted alpha7-Bax and returned alpha7 nAChR to complex with VDAC1 resulting in attenuation of cytochrome c release. 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea cytochrome c, somatic Homo sapiens