Title : Cholesterol-Rich Microdomains Contribute to PAR1 Signaling in Platelets Despite a Weak Localization of the Receptor in These Microdomains.

Pub. Date : 2020 Oct 29

PMID : 33138025






3 Functional Relationships(s)
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1 Targeting the PAR1 pathway by vorapaxar, a PAR1 antagonist, leads to a reduction in ischemic events in cardiovascular patients with a history of myocardial infarction or with peripheral arterial disease. vorapaxar coagulation factor II thrombin receptor Homo sapiens
2 Targeting the PAR1 pathway by vorapaxar, a PAR1 antagonist, leads to a reduction in ischemic events in cardiovascular patients with a history of myocardial infarction or with peripheral arterial disease. vorapaxar coagulation factor II thrombin receptor Homo sapiens
3 Vorapaxar treatment increased the level of PAR1 at the platelet surface, possibly by reducing its endocytosis, while its colocalization with cholesterol-rich microdomains remained weak. vorapaxar coagulation factor II thrombin receptor Homo sapiens