Pub. Date : 2021 Jan
PMID : 33137455
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To elucidate the manner in which p53 deals with glucose-deprived, reactive oxygen species (ROS)-prone conditions in this regard, two isogenic cancer subclones (HN3R-A and HN3R-B) bearing distinct p53 mutations as an in vitro model of intratumoral p53 heterogeneity were identified. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | To elucidate the manner in which p53 deals with glucose-deprived, reactive oxygen species (ROS)-prone conditions in this regard, two isogenic cancer subclones (HN3R-A and HN3R-B) bearing distinct p53 mutations as an in vitro model of intratumoral p53 heterogeneity were identified. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | However, in glucose-deprived and ROS-prone conditions, HN3R-B, the subclone with the original p53 increased the utilization of glutamine by GLS2, thereby maintaining redox homeostasis and ATP. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | Conversely, HN3R-A, the p53-deficient radioresistant subclone displayed an impairment in glutamine usage and high susceptibility to metabolic stresses as well as ROS-inducing agents despite the increased ROS scavenging system. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | Conversely, HN3R-A, the p53-deficient radioresistant subclone displayed an impairment in glutamine usage and high susceptibility to metabolic stresses as well as ROS-inducing agents despite the increased ROS scavenging system. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 6 | Collectively, our findings suggest that p53 governs the alternative utilization of metabolic ingredients, such as glucose and glutamine, in ROS-prone conditions. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 7 | Thus, p53 status may be an important biomarker for selecting cancer treatment strategies, including metabolic drugs and ROS-inducing agents, for recurrent cancers after radiotherapy. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |