Title : IL-18 binding protein (IL-18BP) as a novel radiation countermeasure after radiation exposure in mice.

Pub. Date : 2020 Oct 29

PMID : 33122671






2 Functional Relationships(s)
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1 Furthermore, IL-18BP treatment inhibited the IL-18 downstream target interferon (IFN)-gamma expression in mouse BM, decreased reactive oxygen species (ROS) level in the irradiated mouse heart tissues, attenuated the stress responsive factor GDF-15 (growth differentiation factor-15) and increased the intestine protector citrulline level in total body irradiated mouse serum, implicating that IL-18BP may protect multiple organs from radiation-induced inflammation and oxidative stress. Reactive Oxygen Species interleukin 18 binding protein Mus musculus
2 Furthermore, IL-18BP treatment inhibited the IL-18 downstream target interferon (IFN)-gamma expression in mouse BM, decreased reactive oxygen species (ROS) level in the irradiated mouse heart tissues, attenuated the stress responsive factor GDF-15 (growth differentiation factor-15) and increased the intestine protector citrulline level in total body irradiated mouse serum, implicating that IL-18BP may protect multiple organs from radiation-induced inflammation and oxidative stress. Reactive Oxygen Species interleukin 18 binding protein Mus musculus