Title : Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism.

Pub. Date : 2021 Jan

PMID : 33112806






3 Functional Relationships(s)
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1 Two PDE3B heterozygous variants (p.Arg217Gln and p.Gly392Val) were identified in patients with BAH and HT diagnosed at 18 and 33 yrs of age, respectively. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate phosphodiesterase 3B Homo sapiens
2 PKA activity in frozen tissue was significantly higher in BAH from patients harboring PDE2A and PDE3B variants. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate phosphodiesterase 3B Homo sapiens
3 In conclusion, PDE2A and PDE3B variants were associated with PA caused by BAH. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate phosphodiesterase 3B Homo sapiens