Pub. Date : 2020 Dec 15
PMID : 33098904
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NAD synthetase (NadE) catalyzes the last step in NAD biosynthesis, transforming deamido-NAD+ into NAD+ by a two-step reaction with co-substrates ATP and amide donor ammonia. | nicotinic acid adenine dinucleotide | AT695_RS07645 | Staphylococcus aureus |
| 2 | NAD synthetase (NadE) catalyzes the last step in NAD biosynthesis, transforming deamido-NAD+ into NAD+ by a two-step reaction with co-substrates ATP and amide donor ammonia. | nicotinic acid adenine dinucleotide | AT695_RS07645 | Staphylococcus aureus |
| 3 | We used this structure to perform molecular dynamics simulations of apo-enzyme, enzyme-substrate (NadE with ATP and NaAD) and enzyme-intermediate complexes (NadE with NaAD-AMP) to investigate key binding interactions and explore the conformational transitions and flexibility of the binding pocket. | nicotinic acid adenine dinucleotide | AT695_RS07645 | Staphylococcus aureus |