Pub. Date : 2021 Apr
PMID : 33097833
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, ferroptosis inducers (erastin, sorafenib, and sulfasalazine) activated AMPK/SREBP1 signaling pathway through iron-dependent ferritinophagy, which in turn inhibited BCAT2 transcription. | Sorafenib | branched chain amino acid transaminase 2 | Homo sapiens |
| 2 | Finally, our results demonstrate the synergistic effect of sorafenib and sulfasalazine in downregulating BCAT2 expression and dictating ferroptotic death, where BCAT2 can also be used to predict the responsiveness of cancer cells to ferroptosis-inducing therapies. | Sorafenib | branched chain amino acid transaminase 2 | Homo sapiens |
| 3 | Collectively, these findings identify a novel role of BCAT2 in ferroptosis, suggesting a potential therapeutic strategy for overcoming sorafenib resistance. | Sorafenib | branched chain amino acid transaminase 2 | Homo sapiens |