Title : NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model.

Pub. Date : 2021 Jan

PMID : 33096251






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Oxidative stress induced reactive oxygen species (ROS) are normally controlled at the cellular level by the nuclear factor (erythroid-derived 2)-like 2 (NRF2) a transcription factor that regulates the expression of various antioxidants and detoxifying proteins. Reactive Oxygen Species nuclear factor, erythroid derived 2, like 2 Mus musculus
2 Oxidative stress induced reactive oxygen species (ROS) are normally controlled at the cellular level by the nuclear factor (erythroid-derived 2)-like 2 (NRF2) a transcription factor that regulates the expression of various antioxidants and detoxifying proteins. Reactive Oxygen Species nuclear factor, erythroid derived 2, like 2 Mus musculus
3 Oxidative stress induced reactive oxygen species (ROS) are normally controlled at the cellular level by the nuclear factor (erythroid-derived 2)-like 2 (NRF2) a transcription factor that regulates the expression of various antioxidants and detoxifying proteins. Reactive Oxygen Species nuclear factor, erythroid derived 2, like 2 Mus musculus
4 Oxidative stress induced reactive oxygen species (ROS) are normally controlled at the cellular level by the nuclear factor (erythroid-derived 2)-like 2 (NRF2) a transcription factor that regulates the expression of various antioxidants and detoxifying proteins. Reactive Oxygen Species nuclear factor, erythroid derived 2, like 2 Mus musculus
5 In the presence of ROS, KEAP1 sensor cysteines are directly or indirectly engaged resulting in NRF2 release, nuclear translocation, and activation of its target genes. Reactive Oxygen Species nuclear factor, erythroid derived 2, like 2 Mus musculus