Pub. Date : 2021 Jan
PMID : 33091599
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling. | eupatolide | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | We aimed to evaluate the role of a natural sesquiterpene lactone, eupatolide, in non-small-cell lung cancer (NSCLC) and further explore its underlying mechanism on regulating the activation of signal transducer and activator of transcription 3 (STAT3), which is thought to have carcinogenic function in a variety of malignancies including lung cancer. | eupatolide | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | We aimed to evaluate the role of a natural sesquiterpene lactone, eupatolide, in non-small-cell lung cancer (NSCLC) and further explore its underlying mechanism on regulating the activation of signal transducer and activator of transcription 3 (STAT3), which is thought to have carcinogenic function in a variety of malignancies including lung cancer. | eupatolide | signal transducer and activator of transcription 3 | Mus musculus |
| 4 | Furthermore, eupatolide induced apoptosis by suppressing the activation of STAT3 in NSCLC cells. | eupatolide | signal transducer and activator of transcription 3 | Mus musculus |
| 5 | Sustained activation or knockdown of STAT3 suppressed and enhanced the activity of eupatolide, respectively. | eupatolide | signal transducer and activator of transcription 3 | Mus musculus |
| 6 | This paper is the first to report that eupatolide could effectively inhibit NSCLC progression, suggesting that eupatolide might be utilized as a novel STAT3 inhibitor for treating NSCLC. | eupatolide | signal transducer and activator of transcription 3 | Mus musculus |
| 7 | This paper is the first to report that eupatolide could effectively inhibit NSCLC progression, suggesting that eupatolide might be utilized as a novel STAT3 inhibitor for treating NSCLC. | eupatolide | signal transducer and activator of transcription 3 | Mus musculus |