Pub. Date : 2020
PMID : 33088274
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex. | Nitrous Oxide | nitric oxide synthase 1 | Homo sapiens |
| 2 | We hypothesized that activation of the nNOS/NO pathway in the medial prefrontal cortex (mPFC) might mediate the antidepressant effects of N2O. | Nitrous Oxide | nitric oxide synthase 1 | Homo sapiens |
| 3 | In particular, the antidepressant-like effects of N2O were also antagonized by local nNOS inhibition in the mPFC. | Nitrous Oxide | nitric oxide synthase 1 | Homo sapiens |
| 4 | In summary, our results indicated that N2O exposure enhances BDNF expression levels and burst firing rates in an nNOS activation dependent manner, which might underlie the pharmacological mechanism of the antidepressant-like effects of N2O exposure. | Nitrous Oxide | nitric oxide synthase 1 | Homo sapiens |
| 5 | In summary, our results indicated that N2O exposure enhances BDNF expression levels and burst firing rates in an nNOS activation dependent manner, which might underlie the pharmacological mechanism of the antidepressant-like effects of N2O exposure. | Nitrous Oxide | nitric oxide synthase 1 | Homo sapiens |