Title : Oxidative Stress and Alterations in the Antioxidative Defense System in Neuronal Cells Derived from NPC1 Patient-Specific Induced Pluripotent Stem Cells.

Pub. Date : 2020 Oct 16

PMID : 33081384






2 Functional Relationships(s)
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1 Higher ROS levels, as determined by DCF (dichlorodihydrofluorescein) fluorescence, indicated oxidative stress in all NPC1-deficient cell lines. Reactive Oxygen Species NPC intracellular cholesterol transporter 1 Homo sapiens
2 As catalase is a key enzyme of the cellular antioxidative defense system, we concluded that the lack of catalase contributes to the elevated ROS levels observed in NPC1-deficient cells. Reactive Oxygen Species NPC intracellular cholesterol transporter 1 Homo sapiens