Title : Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.

Pub. Date : 2020 Oct 16

PMID : 33081246






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Upon the evaluation of the inhibitory potency of the newly obtained analogues, nanomolar inhibitory activities were noted for the leucine and isoleucine analogues targeting class I aaRS enzymes, while rather weak inhibitory activity against the corresponding class II aaRSs was observed. Isoleucine alanyl-tRNA synthetase 1 Homo sapiens