Pub. Date : 2021 Jan
PMID : 33074129
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression. | rovalpituzumab tesirine | programmed cell death 1 | Mus musculus |
| 2 | Using a pre-clinical murine SCLC tumor model that expresses Dll3 and has an intact murine immune system, we found that sub-efficacious doses of Rova-T with anti-PD1 resulted in enhanced anti-tumor activity, compared to either monotherapy. | rovalpituzumab tesirine | programmed cell death 1 | Mus musculus |
| 3 | Whole transcriptome analysis as well as flow cytometry and IHC showed that Rova-T activates dendritic cells and increases Ccl5, Il-12, and Icam more than anti-PD1 alone. | rovalpituzumab tesirine | programmed cell death 1 | Mus musculus |
| 4 | Increased tumor expression of PDL1 and MHC1 following Rova-T treatment also supports combination with anti-PD1. | rovalpituzumab tesirine | programmed cell death 1 | Mus musculus |