Pub. Date : 2020
PMID : 33071725
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Knockdown of SNHG14 Alleviates MPP+-Induced Injury in the Cell Model of Parkinson"s Disease by Targeting the miR-214-3p/KLF4 Axis. | mangion-purified polysaccharide (Candida albicans) | small nucleolar RNA host gene 14 | Homo sapiens |
| 2 | SNHG14 knockdown ameliorated MPP+-stimulated damage in SK-N-SH cells, as evidenced by the enhancement in cell viability and the suppression in cell apoptosis and pro-inflammatory cytokine production. | mangion-purified polysaccharide (Candida albicans) | small nucleolar RNA host gene 14 | Homo sapiens |
| 3 | Mechanistically, SNHG14 directly targeted miR-214-3p via binding to miR-214-3p, and SNHG14 knockdown protected SK-N-SH cell from MPP+-stimulated cytotoxicity by upregulating miR-214-3p. | mangion-purified polysaccharide (Candida albicans) | small nucleolar RNA host gene 14 | Homo sapiens |
| 4 | Mechanistically, SNHG14 directly targeted miR-214-3p via binding to miR-214-3p, and SNHG14 knockdown protected SK-N-SH cell from MPP+-stimulated cytotoxicity by upregulating miR-214-3p. | mangion-purified polysaccharide (Candida albicans) | small nucleolar RNA host gene 14 | Homo sapiens |
| 5 | Conclusion: Our current study first demonstrated the protective effect of SNHG14 knockdown on MPP+-stimulated cytotoxicity in SK-N-SH cells at least partially by targeting the miR-214-3p/KLF4 axis, illuminating a promising target for PD intervention and treatment. | mangion-purified polysaccharide (Candida albicans) | small nucleolar RNA host gene 14 | Homo sapiens |