Title : Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic β-cells via the PI3K/Akt/FoxO1 signaling pathway.

Pub. Date : 2021 May

PMID : 33069631






2 Functional Relationships(s)
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1 Moreover, saponins increased the phosphorylation of Akt protein and decreased the protein level of FoxO1, which were both reversed by the PI3K inhibitor ly294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one forkhead box O1 Rattus norvegicus
2 Saponins also increased Akt and PDX-1 mRNA and decreased FoxO1 mRNA, which were both reversed by ly294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one forkhead box O1 Rattus norvegicus