Title : [Up-Regulation of PI3K/Akt Signaling Pathway in H929 Cell Line by Doxycycline Not Beneficial to Its Anti-Myeloma Effect].

Pub. Date : 2020 Oct

PMID : 33067961






3 Functional Relationships(s)
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1 PI3K inhibitor Wortmannin was used to antagonize the up-regulation of p-Akt, and the cell proliferation and p-Akt protein expression level were analyzed by CCK-8 assay and Western blot respectively. Wortmannin AKT serine/threonine kinase 1 Homo sapiens
2 The effect up-regulating p-Akt level by DOX was suppressed when DOX combined with PI3K inhibitor Wortmannin and Wortmannin could enhance the inhibitory effect of DOX in H929 cells. Wortmannin AKT serine/threonine kinase 1 Homo sapiens
3 The effect up-regulating p-Akt level by DOX was suppressed when DOX combined with PI3K inhibitor Wortmannin and Wortmannin could enhance the inhibitory effect of DOX in H929 cells. Wortmannin AKT serine/threonine kinase 1 Homo sapiens