Title : Paclitaxel Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating Circ-BIRC6/miR-877-5p/YWHAZ Axis.

Pub. Date : 2020

PMID : 33061425






3 Functional Relationships(s)
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1 Paclitaxel treatment inhibited the expression of circ-BIRC6 and YWHAZ while promoted the expression of miR-877-5p. Paclitaxel baculoviral IAP repeat-containing 6 Mus musculus
2 Circ-BIRC6 overexpression or miR-877-5p interference reversed the inhibitory effect of paclitaxel on HCC tumorigenesis. Paclitaxel baculoviral IAP repeat-containing 6 Mus musculus
3 Conclusion: Paclitaxel limited HCC tumorigenesis via modulating circ-BIRC6/miR-877-5p/YWHAZ axis, providing a novel therapeutic approach for the treatment of HCC. Paclitaxel baculoviral IAP repeat-containing 6 Mus musculus