Title : Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease.

Pub. Date : 2020 Oct 1

PMID : 33054081






1 Functional Relationships(s)
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1 We observed that long-term (5.5 months) oral treatment with pyridoxamine significantly diminished the adhesive function of neutrophils and platelets and down-regulated the expression of E-selectin and intercellular adhesion molecule-1 on the vascular endothelium in tumor necrosis factor-alpha-challenged sickle cell disease mice. Pyridoxamine intercellular adhesion molecule 1 Mus musculus