Title : Combination of metformin and RG7388 enhances inhibition of growth and induction of apoptosis of ovarian cancer cells through the PI3K/AKT/mTOR pathway.

Pub. Date : 2020 Dec 17

PMID : 33051060






3 Functional Relationships(s)
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1 Combination of metformin and RG7388 enhances inhibition of growth and induction of apoptosis of ovarian cancer cells through the PI3K/AKT/mTOR pathway. RG7388 AKT serine/threonine kinase 1 Homo sapiens
2 Additionally, in vitro and in vivo results showed that MET and/or RG7388 inhibited the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway and their combination had a stronger effect. RG7388 AKT serine/threonine kinase 1 Homo sapiens
3 Our findings suggest that the combination of MET and RG7388 enhances growth inhibition and apoptosis induction of ovarian cancer cells through the PI3K/AKT/mTOR pathway and accumulation of intracellular ROS. RG7388 AKT serine/threonine kinase 1 Homo sapiens