Pub. Date : 2020 Oct 8
PMID : 33049997
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PPAR-alpha Deletion Attenuates Cisplatin Nephrotoxicity by Modulating Renal Organic Transporters MATE-1 and OCT-2. | Cisplatin | solute carrier family 47, member 1 | Mus musculus |
| 2 | On the other hand, multidrug and toxin extrusion 1 (MATE-1) transporter is the main protein that mediates the extrusion of cisplatin into the urine. | Cisplatin | solute carrier family 47, member 1 | Mus musculus |
| 3 | Moreover, we observed that cisplatin induced down-regulation of organic transporters MATE-1 and OCT-2 and that PPAR-alpha deletion restored the expression of these transporters. | Cisplatin | solute carrier family 47, member 1 | Mus musculus |
| 4 | Here, we show for the first time that PPAR-alpha deletion protects against cisplatin nephrotoxicity and that this protection is via modulation of the organic transporters MATE-1 and OCT-2. | Cisplatin | solute carrier family 47, member 1 | Mus musculus |