Pub. Date : 2021 Jan 1
PMID : 33049605
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator. | Isoxazoles | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 2 | Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator. | Isoxazoles | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 3 | Our efforts focusing on isoxazole-type FXR agonists, common nonsteroidal agonists for FXR, led to the discovery a series of novel FXR agonists bearing aryl urea moieties through structural simplification of LJN452 (phase 2). | Isoxazoles | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 4 | Our efforts focusing on isoxazole-type FXR agonists, common nonsteroidal agonists for FXR, led to the discovery a series of novel FXR agonists bearing aryl urea moieties through structural simplification of LJN452 (phase 2). | Isoxazoles | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |
| 5 | Our efforts focusing on isoxazole-type FXR agonists, common nonsteroidal agonists for FXR, led to the discovery a series of novel FXR agonists bearing aryl urea moieties through structural simplification of LJN452 (phase 2). | Isoxazoles | nuclear receptor subfamily 1, group H, member 4 | Mus musculus |