Title : ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.

Pub. Date : 2021 Jan 15

PMID : 33039867






5 Functional Relationships(s)
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Protein Name
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1 ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. sodium arsenite tumor protein p53 Homo sapiens
2 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite tumor protein p53 Homo sapiens
3 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite tumor protein p53 Homo sapiens
4 Unexpectedly, p21 was also elevated in NaAsO2-exposed p53-null PC-3 cells. sodium arsenite tumor protein p53 Homo sapiens
5 These results suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. sodium arsenite tumor protein p53 Homo sapiens