Pub. Date : 2020 Oct
PMID : 33021976
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using atomistic simulations, we show that in the absence of cholesterol in the SSD, the luminal domains of NPC1 are highly dynamic, resulting in the disengagement of the NTD from the rest of the protein. | Phenobarbital | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | The binding of cholesterol to the SSD of NPC1 allosterically suppresses the conformational dynamics of the luminal domains resulting in an upright NTD conformation. | Phenobarbital | NPC intracellular cholesterol transporter 1 | Homo sapiens |