Title : Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain.

Pub. Date : 2020 Oct

PMID : 33021976






2 Functional Relationships(s)
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1 Using atomistic simulations, we show that in the absence of cholesterol in the SSD, the luminal domains of NPC1 are highly dynamic, resulting in the disengagement of the NTD from the rest of the protein. Phenobarbital NPC intracellular cholesterol transporter 1 Homo sapiens
2 The binding of cholesterol to the SSD of NPC1 allosterically suppresses the conformational dynamics of the luminal domains resulting in an upright NTD conformation. Phenobarbital NPC intracellular cholesterol transporter 1 Homo sapiens