Pub. Date : 2021 Jan
PMID : 33007330
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In particular, we found that, in addition to AKT and ERK1/2 activation, FGFR1-induced activation of IRS1 and IGF1R, key regulators connecting metabolism and cancer, was associated with metformin resistance. | Metformin | insulin receptor substrate 1 | Homo sapiens |
| 2 | Targeting IRS with IRS1 KO or IRS inhibitor NT157 significantly sensitized FGFR1 overexpressing cells to metformin. | Metformin | insulin receptor substrate 1 | Homo sapiens |
| 3 | Our study highlights the significance of FGFR1 status and IRS1 activation in metformin-resistance, which will facilitate the development of strategies targeting FGFR overexpression-associated metformin resistance. | Metformin | insulin receptor substrate 1 | Homo sapiens |