Title : Macrocyclic polyketides with siderophore mode of action from marine heterotrophic Shewanella algae: Prospective anti-infective leads attenuate drug-resistant pathogens.

Pub. Date : 2021 May

PMID : 33006801






2 Functional Relationships(s)
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1 The macrocyclic polyketide compounds exhibited wide-spectrum of anti-infective potential against clinically significant vancomycin-resistant Enterococcus faecalis (VREfs), methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumonia with minimum inhibitory concentration of about 1-3 microg mL-1 , insomuch as the antibiotics chloramphenicol and ampicillin were active at >= 6.25 microg mL-1 . Polyketides L1 cell adhesion molecule Mus musculus
2 The macrocyclic polyketide compounds exhibited wide-spectrum of anti-infective potential against clinically significant vancomycin-resistant Enterococcus faecalis (VREfs), methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Klebsiella pneumonia with minimum inhibitory concentration of about 1-3 microg mL-1 , insomuch as the antibiotics chloramphenicol and ampicillin were active at >= 6.25 microg mL-1 . Polyketides L1 cell adhesion molecule Mus musculus