Pub. Date : 2020 Nov
PMID : 33000204
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KCNQ1OT1 contributes to sorafenib resistance and programmed death-ligand-1-mediated immune escape via sponging miR-506 in hepatocellular carcinoma cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 2 | The aim of the present study was to investigate the role of KCNQ1OT1 in sorafenib resistance and immune escape of HCC cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 3 | KCNQ1OT1 and PD-L1 were found to be upregulated and miR-506 was downregulated in sorafenib-resistant HCC tissues and cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 4 | Furthermore, KCNQ1OT1 knockdown reduced the IC50 value of sorafenib, suppressed cell metastasis and promoted apoptosis in sorafenib-resistant HCC cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 5 | Furthermore, KCNQ1OT1 knockdown reduced the IC50 value of sorafenib, suppressed cell metastasis and promoted apoptosis in sorafenib-resistant HCC cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 6 | Moreover, KCNQ1OT1 knockdown changed the tumor microenvironment and T-cell apoptosis in a sorafenib-resistant HCC/T-cell co-culture model. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 7 | In addition, it was demonstrated that KCNQ1OT1 functioned as a competing endogenous RNA of miR-506 and increased PD-L1 expression in sorafenib-resistant HCC cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 8 | miR-506 inhibition abolished the effects of KCNQ1OT1 knockdown on sorafenib sensitivity, tumor growth, the tumor microenvironment and T-cell apoptosis. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 9 | In conclusion, KCNQ1OT1 knockdown inhibited sorafenib resistance and PD-L1-mediated immune escape by sponging miR-506 in sorafenib-resistant HCC cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |
| 10 | In conclusion, KCNQ1OT1 knockdown inhibited sorafenib resistance and PD-L1-mediated immune escape by sponging miR-506 in sorafenib-resistant HCC cells. | Sorafenib | KCNQ1 opposite strand/antisense transcript 1 | Homo sapiens |