Title : Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

Pub. Date : 2020 Oct

PMID : 32999459






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 In the absence of WRN, the expanded TA-dinucleotide repeats are susceptible to cleavage by the MUS81 nuclease, leading to massive chromosome shattering. ta-dinucleotide MUS81 structure-specific endonuclease subunit Homo sapiens