Title : Metabolic understanding of disulfide reduction during monoclonal antibody production.

Pub. Date : 2020 Nov

PMID : 32997205






1 Functional Relationships(s)
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1 Additionally, glucose 6-phosphate dehydrogenase (G6PD) activity and an increased (>= 300%) lactate/pyruvate molar ratio (lac/pyr) during production cell culture correlated to disulfide reduction risk, suggesting a metabolic shift to the pentose phosphate pathway (PPP). Pentosephosphates glucose-6-phosphate 1-dehydrogenase Cricetulus griseus