Title : Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates.

Pub. Date : 2021 Apr 5

PMID : 32995773






2 Functional Relationships(s)
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1 We then identified the heptad repeat 2 (HR2) stalk as a major cause of spike metastability, designed an HR2-deleted glycine-capped spike (S2GDeltaHR2), and displayed S2GDeltaHR2 on three SApNPs with high yield, purity, and antigenicity. Glycine surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 We then identified the heptad repeat 2 (HR2) stalk as a major cause of spike metastability, designed an HR2-deleted glycine-capped spike (S2GDeltaHR2), and displayed S2GDeltaHR2 on three SApNPs with high yield, purity, and antigenicity. Glycine surface glycoprotein Severe acute respiratory syndrome coronavirus 2