Title : TARPs Modulate Receptor-Mediated Paired-Pulse Depression and Recovery from Desensitization.

Pub. Date : 2020 Oct 21

PMID : 32994336






2 Functional Relationships(s)
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1 Thus, isoform-specific differences in TARP modulation of recovery from desensitization influence receptor responses to repeated brief applications of glutamate, and these differences may impact frequency-dependent synaptic signaling in the mammalian central nervous system.Significance Statement:AMPA receptors are major determinants of excitatory synaptic strength. Glutamic Acid TCR gamma alternate reading frame protein Homo sapiens
2 We observed that the TARP isoforms and duration of glutamate application uniquely modulate time constants and the proportion of fast and slow components through a previously unidentified TARP domain. Glutamic Acid TCR gamma alternate reading frame protein Homo sapiens