Title : Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses.

Pub. Date : 2021 Feb 25

PMID : 32976550






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In vitro, inducible Treg differentiation from naive CD4+ T cells was enhanced by IRX4204; in vivo, IRX4204 increased the conversion of donor Foxp3- T cells into peripheral Foxp3+ Tregs in GVHD mice. treg forkhead box P3 Mus musculus
2 In vitro, inducible Treg differentiation from naive CD4+ T cells was enhanced by IRX4204; in vivo, IRX4204 increased the conversion of donor Foxp3- T cells into peripheral Foxp3+ Tregs in GVHD mice. treg forkhead box P3 Mus musculus
3 Using Foxp3 lineage tracer mice in which both the origin and current FoxP3 expression of Tregs can be tracked, we demonstrate that IRX4204 supported Treg stability. treg forkhead box P3 Mus musculus