Pub. Date : 2020
PMID : 32974183
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SREBP-2 binds to the sterol regulatory elements (SREs) in the promoters of its target genes and activates the transcription of mevalonate pathway genes, such as HMG-CoA reductase (HMGCR), mevalonate kinase and other key enzymes. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | SREBP-2 binds to the sterol regulatory elements (SREs) in the promoters of its target genes and activates the transcription of mevalonate pathway genes, such as HMG-CoA reductase (HMGCR), mevalonate kinase and other key enzymes. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 3 | We then found that SREBP-2 and its regulated enzymes, including HMGCR, FPPS, SQS, and DHCR4 from the mevalonate pathway, participate in the progression of various cancers, including prostate, breast, lung, and hepatocellular cancer, as potential targets. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |