Pub. Date : 2020
PMID : 32974014
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis. | pyrimidine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Treatment with the allosteric mTORC1 inhibitor rapamycin abrogates CAD phosphorylation and pyrimidine synthesis induced by formate. | pyrimidine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Conclusions: We conclude that formate activates mTORC1 and induces pyrimidine synthesis via the mTORC1-dependent phosphorylation of CAD. | pyrimidine | CREB regulated transcription coactivator 1 | Mus musculus |