Pub. Date : 2020 Nov 12
PMID : 32970989
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | On cells, spike protein binding depends on both heparan sulfate and ACE2. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | Unfractionated heparin, non-anticoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike protein binding and/or infection by pseudotyped virus and authentic SARS-CoV-2 virus. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |