Title : Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.

Pub. Date : 2020 Sep 22

PMID : 32966798






2 Functional Relationships(s)
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1 Pharmacologically limiting RyR2 open time with the R-carvedilol enantiomer (but not racemic carvedilol) prevents and rescues neuronal hyperactivity, memory impairment, and neuron loss even in late stages of AD. Carvedilol ryanodine receptor 2, cardiac Mus musculus
2 Pharmacologically limiting RyR2 open time with the R-carvedilol enantiomer (but not racemic carvedilol) prevents and rescues neuronal hyperactivity, memory impairment, and neuron loss even in late stages of AD. Carvedilol ryanodine receptor 2, cardiac Mus musculus