Pub. Date : 2020 Sep 18
PMID : 32957369
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin inhibits TNF-alpha induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro. | Quercetin | tumor necrosis factor | Homo sapiens |
| 2 | OBJECTIVE: The aim of this study was to investigate the mechanisms of how quercetin inhibits tumor necrosis factor alpha (TNF-alpha) induced human umbilical vein endothelial cells (HUVECs) apoptosis and inflammation. | Quercetin | tumor necrosis factor | Homo sapiens |
| 3 | OBJECTIVE: The aim of this study was to investigate the mechanisms of how quercetin inhibits tumor necrosis factor alpha (TNF-alpha) induced human umbilical vein endothelial cells (HUVECs) apoptosis and inflammation. | Quercetin | tumor necrosis factor | Homo sapiens |
| 4 | TNF-alpha induced elevated apoptosis rates and upregulation of VCAM-1, ICAM-1, and E-selectin were meaningfully reduced in HUVECs by pretreatment with quercetin. | Quercetin | tumor necrosis factor | Homo sapiens |
| 5 | CONCLUSION: Results indicate that quercetin could suppress TNF-alpha induced apoptosis and inflammation by blocking NF-kappaB and AP-1 signaling pathway in HUVECs, which might be one of the underlying mechanisms in treatment of coronary heart disease. | Quercetin | tumor necrosis factor | Homo sapiens |