Title : Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia.

Pub. Date : 2019 Aug 1

PMID : 32952998






1 Functional Relationships(s)
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1 A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in vitro anti-leukaemic activity and calculated "drug-likeness" properties, in vitro and in vivo pharmacokinetics studies and hERG liability testing. parthenolide ETS transcription factor ERG Homo sapiens